The new Enterprise Library Data Access Application Block (Oh my gawd that is a mouthfull) uses some other part of Enterprise Library 2.0 called IConfigurationSource. This is pretty cool, but the DAAB (because Data Access Application Block is such wordy) bit of it looks an aweful lot like Mono.Data.ProviderFactory.
http://codebetter.com/blogs/david.hayden/archive/2006/01/08/136360.aspx
http://little.xmtp.net/blog/2005/11/22/more-proper-data-abstractions-in-net-and-mono-applications/